Know what's inside.

In vivo DMPK Services

Flexibility in study design and meeting demanding time lines is the strength of the GBA Pharma in vivo team. We offer DMPK studies in mice, rats, guinea pigs and hamsters. Further preclinically relevant species (e.g. dog, monkey) are available in cooperation with our partners. The service offering includes complete workflow studies (in-life part, bioanalysis and PK evaluation).

  • Rat
  • Mouse
  • Guinea pig
  • Hamster
  • Dog*
  • Mini pig*
  • Monkey*
Application Routes
  • Intravenous (bolus or infusion)
  • Oral (liquid, capsules)
  • Intraperitoneal
  • Subcutaneous (incl. osmotic minipumps)
  • Intramuscular
  • Intradermal
  • Intranasal
  • Topical
  • Intravitreal
  • Single, repeated and cassette dosing
Surgical Methods
  • Cannulation (rat)
    –   vena jugularis (neck or head attachment)
    –   portal vein (e.g. for evaluation of first-pass effect)
    –   bile duct (e.g. for evaluation of entero-hepatic circulation)
Sampling Methods
  • Jugular catheter
  • Tail vein or artery
  • Sublingual vein
  • Plexus retrobulbaris
  • Heart puncture (terminal)
  • Dried blood spots (microsampling)
  • Tissue perfusion
  • Metabolic cage
Sample Types
  • Whole blood, plasma, dried blood spots
  • Excreta
  • Urine
  • Faeces
  • Bile
  • Cerebrospinal fluid
  • Tissues/organs
  • CSF from cisterna magna in rats (terminal)
  • All markers that can be quantified in biological matrices by validated immuno-assay or LC-MS-methods
  • Sample processing for histology
  • Haematology, flow cytometry
Exploratory PK Studies
  • Dried bloodspot / snapshot PK
  • Cassette dosing
  • Major metabolites
Full PK Studies
  • Dose proportionality
  • Organ distribution, excretion, mass balance
  • Metabolite identification
  • First pass effect

All experimental procedures are approved by and conducted in accordance with the regulations of the local Animal Welfare authorities. The in vivo department is frequently audited by clients with positive results.

*in cooperation

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