The integrity of a container is especially important for reasons that are quite understandable. In general, this is checked using microbiological tests (microbial ingress into the packaging) or color tests (dye ingress into the packaging).
GBA Pharma has established methods for chemical testing using a methylene blue solution (called the "blue bath test") for a variety of sealing material combinations. In addition to the sample containers, these methods utilize both positive and negative controls.
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